Progress of non-coding RNA in the kidney development / 国际儿科学杂志

ABSTRACT

Non-coding RNAs have been classified by the length of nucleotides in short, medium and long non-coding RNAs.Typically, long non-coding RNA and microRNA regulate the development of the kidney via Six2, Hnf-1β, Bim or mTOR signaling pathways, etc.Aberrant regulation, however, will lead to congenital anomalies of the kidney and urinary tract(CAKUT). Furthermore, the environment could affect the expression activity of non-coding RNAs at the same time.This article reviews the precise role of non-coding RNAs in the development of kidney and during the formation of CAKUT, besides, the specific regulation mechanisms are explained.