Nonthyroidal illness syndrome in critical ill children / 国际儿科学杂志

ABSTRACT

Nonthyroidal illness syndrome(NTIS)is very common in critically ill patients, and its mechanism is complex, involving deiodination, hypothalamus-pituitary-thyroid axis, protein binding, cell uptake, receptor regulation and so on.The thyroid hormone level in critically ill children has prognostic significance, and children may have lower levels of thyroid hormones than adults at the time of NTIS.For a long time, it has been believed that NTIS is a self-protective mechanism of the body in the state of disease, so there is no need to intervene.But in recent years, more and more studies have found that thyroid hormone replacement therapy seems to bring benefits to critically ill patients, but there is still a lack of strong clinical evidence, which is still controversial.This article will review the new progress in the study of NTIS in critically ill children in recent years.