Advances in the effect and mechanism of Faecalibacterium prausnitzii on immune regulation of inflammatory bowel disease / 国际儿科学杂志

ABSTRACT

Inflammatory bowel disease is a common digestive tract disease, and its incidence rate is increasing year by year.Changes of intestinal microecology in patients with inflammatory bowel disease are mainly manifested by the decreased species richness of intestinal microorganisms, among which the significant reduction of Faecalibacterium prausnitzii is one of its important characteristics.In addition, Faecalibacterium prausnitzii participates in the immune regulation of inflammatory bowel disease and plays an important role in the occurrence and development of inflammatory bowel disease.In this article, we reviewed the role and mechanism of Faecalibacterium prausnitzii involved in the immune regulation of inflammatory bowel disease by inhibiting inflammatory pathways, regulating the differentiation and function of Treg cells, and repairing intestinal mucosal barrier.By summarizing the specific mechanisms and roles of Faecalibacterium prausnitzii in the intestine, we hope to provide a basis for clinical treatment and research of inflammatory bowel disease.