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Clinical efficacy of donepezil combined with oxiracetam in the treatment of vascular dementia after acute cerebral infarction / 国际生物医学工程杂志
International Journal of Biomedical Engineering ; (6): 46-49, 2020.
Article in Chinese | WPRIM | ID: wpr-863196
ABSTRACT

Objective:

To investigate the clinical efficacy of donepezil combined with oxiracetam in the treatment of vascular dementia after acute cerebral infarction.

Methods:

Sixty patients with vascular dementia after acute cerebral infarction were randomly divided into control group ( n=30) and combined administration group ( n=30). Patients in the control group orally received oxiracetam 3 times daily (0.8 g/time), and patients in the combination group orally received donepezil once daily (5 mg/time) based on the treatment of oxiracetam. The treatment was lasted for 4 weeks. Before and after treatments, patients were evaluated with the mini-mental state examination (MMSE), and the levels of serum interleukin 18 (IL-18), tumor necrosis factor-α (TNF-α), matrix metalloproteinase 9 (MMP9) and vascular endothelial growth factor (VEGF).

Results:

After the treatment, the MMSE score of all patients were significantly higher than before treatments (all P<0.05), serum IL-18, TNF-α, and MMP9 levels decreased (all P<0.05), and serum VEGF levels increased ( P<0.05). Comparing with the control group, the MMSE score of patients in the combined administration group were higher ( P<0.05), serum IL-18, TNF-α, and MMP9 levels were lower (all P<0.05), and serum VEGF levels were higher ( P<0.05) after the treatment.

Conclusions:

The treatment of Donepezil combined with oxiracetam can improve the clinical symptoms of patients with vascular dementia, and its mechanism may involve inhibition of inflammatory response, inhibition of apoptosis and promotion of vascular endothelial cell growth.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Biomedical Engineering Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Biomedical Engineering Year: 2020 Type: Article