Research progress of small molecule active peptides in bone tissue engineering / 国际生物医学工程杂志

ABSTRACT

Although bone tissue has a certain ability of self-healing, bone transplantation is still needed for bone defects beyond the limit of self-healing. Calcium and phosphorus materials, such as hydroxyapatite and tricalcium phosphate, are currently common biological scaffold materials for bone repair, but these bioactive materials often lack osteoinductive activity, ability of promoting seed cell adhesion and angiogenesis. The traditional method to remedy these defects is to use growth regulators such as bone morphogenetic proteins to regulate the osteogenesis process on bioactive materials. However, these active factors often have the disadvantage of high cost and can not be used for a long time. In order to solve the above problems, a variety of small molecule active peptides were developed and played a good osteogenic effect. In this paper, a variety of common small molecule active peptides that induce osteogenesis were summarized and their research progress was reviewed.