Meta-analysis of the function of carbon nanoparticles use in the surgery of thyroid cancers / 国际外科学杂志

ABSTRACT

Objective:To systematically evaluate the role of nanocarbon in the surgical treatment of thyroid cancer.Method:Searched Pubmed database, Web of Science, Cochrane Library, CNKI database, Wanfang database and VIP database for researches related to nanocarbon and thyroid cancer. The search key words included nano carbon, nano-carbon, carbon nanoparticles, nano-carbon parathyroid negative imaging technique, thyroid neoplasms, thyroid cancer, thyroid carcinoma. And also manually retrieved article references. The search time was from the establishment of the database to March 10, 2020. Two researchers separately screened and sorted out the data, and evaluated the quality of the articles and evaluated the publication bias. Revman 5.3 was used for data analysis.Results:Twenty-six randomized controlled studies were included, with a total of 2291 patients, including 1149 in the test group and 1142 in the control group. The results showed that the postoperative complications rate of the test group using nanocarbon was significantly lower than that of the blank control group, and the differences were statistically significant, including the parathyroid erroneous excision rate ( OR=0.24, 95% CI 0.16-0.34, P<0.001), the incidence of postoperative hypoparathyroidism ( OR=0.38, 95% CI 0.28-0.52, P<0.001), the incidence of postoperative hypocalcemia ( OR=0.40, 95% CI 0.30-0.54, P<0.001) and the recurrent laryngeal nerve injury rate ( OR=0.50, 95% CI 0.31-0.81, P<0.001). Conclusion:The use of nanocarbon tracing technology during the operation can reduce the complications of thyroid cancer resection and is worthy of clinical use.