Data mining on the rules of prescription in the treatment of infertility (female) in Dictionary of Traditional Chinese Medicine Prescriptions / 国际中医中药杂志

ABSTRACT

Objective:To analyze the compatibility of prescriptions for infertility (female) in the Dictionary of Traditional Chinese Medicine Prescriptions. Methods:The prescriptions for infertility (female) in the Dictionary of Traditional Chinese Medicine Prescriptions were collected and analyzed by association rules analysis, mutual information method, complex system entropy clustering and unsupervised entropy hierarchical clustering with the Traditional Chinese Medicine Inheritance Support System (v2.5). Results:A total of 302 prescriptions were collected for the treatment of infertility (female), involving 352 kinds of traditional Chinese medicine, with warm nature as the main property and sweet taste as the main flavor, followed by pungent and bitter flavor, mainly belonging to liver, spleen, kidney and heart meridian. Thirty seven prescriptions were used more than 30 times, and the top ten were Angelicae sinensis radix, Chuanxiong rhizoma, Poria, Rehmanniae radix praeparata, Paeoniae radix alba, Ginseng radix et rhizoma, Cyperi rhizoma, Atractylodis macrocephalae rhizoma, Cinnamomi cortex and Rehmanniae radix. There were 40 common drug combinations for 60 times, the top four including Angelicae sinensis radix- Chuanxiong rhizoma, Angelicae sinensis radix- Paeoniae radix alba, Rehmanniae radix praeparata- Angelicae sinensis radix and Chuanxiong rhizoma-Paeoniae radix alba. Thirteen core combinations of 3-5 herbs were obtained by complex system entropy clustering, and 13 new prescriptions were formed by further clustering. Conclusions:According to the Dictionary of Traditional Chinese Medicine Prescriptions, prescriptions for infertility (female) are mainly used to regulate qi and blood, nourish the five zang organs, and properly matching with those for regulating qi to open depression, drying dampness to dissipate phlegm, and warming meridians to dredge stagnation.