Effect of Xuanfei-Liyan patch on immune function in recurrent respiratory tract infection children / 国际中医中药杂志

ABSTRACT

Objective:To investigate the effect of Xuanfei-Liyan patch on T lymphocyte subsets in recurrent respiratory tract infection children. Methods:One hundred twenty recurrent respiratory tract infections children who met the inclusion criteria in the Health service Center of Youyi Street community of Shanghai Baoshan District from January 2017 to January 2019 were selected as the study subjects. A random number table method was used to divide them into observation group and control group with 60 cases in each group. The control group was given with conventional treatment measures. On the basis of treatment in the control group, the observation group was treated with Xuanfei-Liyan patch once every other day. Two groups were treated for 2 months. The forced expiratory volume (FEV1) and maximum peak flow rate (PEF) were measured with a pulmonary function meter, the recovery time of symptoms and signs were recorded, the levels of CD3 +, CD4 +, and CD8 + were detected by flow cytometry, and clinical efficacy was evaluated. Results:The total effective rate of the observation group and the control group was 98.33% and 86.67%, respectively, and the difference was statistically significant ( χ2=4.324, P=0.038). After treatment, FEV1 (1.61 ± 0.22 L vs. 1.30 ± 0.19 L, t=8.261) and PEF (122.93 ± 14.49 L/min vs. 103.05 ± 12.06 L/min, t=8.168) in the observation group were significantly higher than those in the control group ( P<0.01). The time of temperature recovery, cough relief, ralogue disappearance, and pharyngeal normalcy in the observation group were significantly shorter than those in the control group ( t value were 16.851, 15.667, 12.387, 8.746, respectively, all Ps<0.001). After treatment, the levels of CD3 + and CD4 + were significantly higher than those in the control group ( t=3.656 and 4.667, respectively, all Ps<0.01), and level of CD8 + was significantly lower than that of the control group ( t=5.149, P<0.01). Conclusions:The Xuanfei-Liyan patch sticking point application can improve the pulmonary function and immunity of children with recurrent respiratory tract infection, improve clinical symptoms and curative effect.