Clinical and pathological features and treatment experience of breast cancer patients aged over 70 years / 中华内分泌外科杂志

ABSTRACT

Objective:To investigate the clinicopathological characteristics and treatment methods of breast cancer patients aged over 70 years.Methods:Retrospective analysis was performed on the clinical data of 116 cases of breast cancer who were admitted to the Beijing Sixth Hospital from Jan.2008 to Jan.2018 and were over 70 years old.Results:All the 116 cases were female with an average age of 73 years and a course of disease ranging from 1 week to 5 years. The main surgical methods of the patients in this group were modified radical mastectomy (total mastectomy and axillary dissection were 70.2% and 61.3%, respectively) , postoperative pathological invasive cancer accounted for 85.3% (99/116) , mucinous cancer and other special types of cancer accounted for 6.9% (8/116) , triple-negative breast cancer accounted for 11.1% (11/99, and HER2-positive breast cancer accounted for 18.2% (18/99) . The proportion of patients receiving postoperative chemotherapy was 48.3% (56/116) and that receiving endocrine therapy was 55% (61/116) . The median follow-up time was 44 months, the postoperative recurrence rate was 5.1% (5/99) , and during the follow-up time, 8 cases of breast cancer-related deaths and 17 cases of disease-related deaths occurred.Conclusions:Geriatric breast cancer patients have special characteristics of clinicopathology and molecular biology, with a long course of disease, relatively late disease period, many concomitant diseases, poor tolerance to chemotherapy, and poor compliance with endocrine therapy. Surgery and endocrine therapy are the main and effective treatment methods.