Application of dinoprostone and phloroglucinol in painless delivery in full-term pregnancy patients / 中华内分泌外科杂志

ABSTRACT

Objective:To investigate the specific effects of combined use of dinoprostone and phloroglucinol in painless delivery in full-term pregnant patients.Methods:100 primiparas admitted from Oct. 2016 to Oct. 2018 in our hospital were enrolled in this study. The 100 primiparas all met the following conditions full-term pregnancy induced labor, singletons, no local complications, no maternity contraindications, no prostaglandins contraindications, no anesthesia contraindications and bishop scores of cervical were six points or less. By using the random number table method, they were divided into observation group and control group in the two groups, 50 cases in each group. Patients in the control group were induced labor by intravenous oxytocin infusion, and labor analgesia was performed under anesthesia when the opening of uterine orifice was 3 cm. In the observation group, labor induction mode was changed on the basis of the control group. Dinoprostone was used to induce labor at the posterior vaginal vault of the patient, and intravenous infusion of phloroglucinol was performed when the opening of uterine orifice was 3 cm and labor analgesia was performed under anesthesia. The cervical maturation rate, labor induction rate, specific labor process, pain degree and pregnancy outcome were compared between the two groups.Results:The effective rate of cervical maturation in the observation group (94.00%) was significantly higher than that in the control group (76.00%) , and the difference was statistically significant ( P<0.05) . The comparison results of pain degree between the two groups showed that 36 cases (72.00%) with grade I pain in the observation group, significantly higher than 24 cases (48.00%) of the control group, and 2 cases (4.00%) with grade III pain in the observation group, significantly lower than 8 cases (16.00%) in the control group, with statistically significant differences ( P<0.05) . There was no significant difference between the two groups in term of the number of patients with grade II pain patients ( P>0.05) . There were 46 cases (92.00%) of successful labor induction in the observation group and 38 cases (76.00%) in the control group. The success rate of labor induction in the observation group was significantly higher than that in the control group, with statistically significant difference ( P<0.05) . The incubation period, active period, first stage and total length of labor in the observation group were significantly shorter than those in the control group, with statistically significant differences ( P<0.05) . There was no significant difference in the length of the second and third stages of labor between the two groups ( P>0.05) . There was no significant difference in neonatal asphyxia rate, Apgar score and postpartum blood loss between the two groups ( P>0.05) . Conclusion:The application of dinoprostone in painless delivery can effectively shorten the length of labor, and has a good effect on pain relief and smooth delivery, which can further accelerate the labor process of patients, accelerate cervical maturation, soften the cervix of patients, reduce spasm, and improve the rate of labor induction by combining with phloroglucinol, with more accurate efficacy.