Relationship between plasma fibrinogen level and p53 protein expression of tumor tissue in patients with breast cancer / 中华内分泌外科杂志

ABSTRACT

Objective:To investigate the relationship between plasma fibrinogen (FBG) level and p53 protein expression of tumor tissue in breast cancer, and to study the relationship between the parameters of plasma FBG level and p53 protein expression in tumor tissue and the prognosis of breast cancer.Methods:A total of 177 breast cancer patients who underwent surgery in the Second Affiliated Hospital of Hainan Medical University between Jan. 2012 and Oct. 2016 were included in the study. The data, including the general clinicopathological characteristics, the expression of p53 protein with immumohistochemical (IHC) staining, and plasma FBG level within 1 week before surgery, were collected. Chi-square test was used to analyze the relationship between the different levels of plasma FBG and the parameters of general clinicopathological characteristics and p53 protein, and binary Logistic regression was used for multivariate analysis. Kaplan-meier survival analysis and COX regression analysis were used for univariate analysis and multivariate analysis of IDFS, respectively.Results:Univariate analysis showed that plasma FBG>2.75 g/L had significant positive correlation with age>50 and positive p53 expression in tumor tissue ( P values were <0.001 and 0.006, respectively) . Multivariate analysis showed that positive p53 expression in tumor tissue ( OR 2.256, 95% CI 1.192 to 4.271, P<0.001) and age>50 years ( OR 3.712, 95% CI 1.967 to 7.002, P<0.001) were independent correlation factors for plasma FBG>2.75 g/L. Kaplan-Meier survival analysis results showed that the aged>50 years, T>2 cm, lymph node metastasis, Ⅲ stage, plasma FBG>2.75 g/L, positive p53 expression in tumor tissue were adverse prognostic factors of IDFS. COX regression analysis results showed that plasma FBG>2.75 g/L ( HR 6.226, 95% CI 3.863 to 10.033, P<0.001) , positive p53 expression in tumor tissue ( HR 1.864, 95% CI 1.133 to 3.066, P=0.014) and Ⅲ stage ( HR 10.382, 95% CI 5.942 to 18.141, P<0.001) were adverse prognostic factors of IDFS, and adjuvant endocrine therapy ( HR 0.427, 95% CI 0.275 to 0.663, P<0.001) was a favourable prognostic factor for IDFS. Conclusions:The expression of p53 protein was significantly correlated with high plasma FBG level in breast cancer. Both p53 protein expression and high plasma FBG level are associated with poor prognosis of breast cancer. On the basis of traditional pathological prognostic indicators, the detection of plasma FBG and p53 protein in tumor tissue may contribute to increase the prognostic information in breast cancer.