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Progress and challenge in tuberculosis vaccine research / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics ; (24): 721-725, 2020.
Article in Chinese | WPRIM | ID: wpr-864093
ABSTRACT
Tuberculosis(TB) is a serious threat to children′s health.The World Health Organization reported that there were almost 10 million new TB cases(including 1.12 million pediatric patients) and 1 240 000 deaths(173 000 were children) globally in 2018." Find.Treat.All.#End TB" points out that an effective vaccination is the most effective method for the control of infectious diseases.It is difficult to diagnose TB in children in the early stage due to atypical clinical symptoms of TB, leading to treatment delay.Therefore, vaccination is essential for the prevention of pediatric TB.However, the problems of limited immune duration, unclear protective effect and increasing the risk of BCG disease existing in Bacillus Calmette-Guerin(BCG), the only TB vaccine widely used in the world, necessitate the development of new vaccines.The progress in and challenges of research on TB vaccines were reviewed in this article, which helps provide reference for the development of new vaccines and seeking solutions of above problems.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Applied Clinical Pediatrics Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Applied Clinical Pediatrics Year: 2020 Type: Article