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Primary immunodeficiency diseases susceptible to mycobacteria in children / 中华实用儿科临床杂志
Article in Zh | WPRIM | ID: wpr-864097
Responsible library: WPRO
ABSTRACT
Primary immunodeficiency diseases (PIDs) refer to immune function decrease and deficiency or immune regulation function imbalance resulted from immune cell or immunomolecular defects caused by single gene mutation.Children with PIDs are prone to develop infectious diseases.Because the immune mechanisms of hosts infected by different pathogens infecting vary, different types of PIDs are relatively susceptible to different pathogens.A number of studies have indicated that some PIDs children are more likely to develop Bacilles Calmétte-Guerin infection, severe tuberculosis and non- Tuberculous mycobacteria severe infection.In this review, several major primary immunodeficiency diseases closely related to the susceptibility of mycobacteria were summarized, including chronic granulomatous disease, severe combined immunodeficiency disease, mendelian susceptibility to mycobacterial disease, and high IgM syndrome, in order to provide a theoretical basis for early identification of such diseases.
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Applied Clinical Pediatrics Year: 2020 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Chinese Journal of Applied Clinical Pediatrics Year: 2020 Type: Article