Effect of Helicobacter pylori Eradication on Functional Dyspepsia
Journal of Neurogastroenterology and Motility
;
: 233-243, 2013.
Article
in English
| WPRIM
| ID: wpr-86416
ABSTRACT
BACKGROUND/AIMS:
This study evaluated the effect of Helicobacter pylori eradication on functional dyspepsia (FD), and the relationship between the changes of histological gastritis and FD symptom responses.METHODS:
A total of 213 FD patients diagnosed by Rome III criteria were consecutively enrolled. H. pylori tests and gastritis grade by the Sydney system were performed before and 1 year after the proton pump based-eradication therapy for 7 days. Serum levels of pepsinogen, and genetic polymorphisms IL-6, IL-8 and IL-10 were investigated.RESULTS:
Total of 91 patients completed the 1 year follow-up. When the response rate of dyspepsia was compared at 1 year between the non-eradicated group (n = 24) and eradicated group (n = 67), each group showed complete response of 62.5% and 62.7%; satisfactory response (> or = 50%) of 0.0% and 19.4%; partial response (< 50%) of 12.5% and 11.9%; and refractory response of 25.0% and 6.0%, respectively (P = 0.015). In addition, the responder group (complete + satisfactory response) at 1 year showed improvement of activity and chronic inflammation in both the antrum and corpus (all P < 0.001). Multivariate analysis showed that H. pylori eradication (OR, 5.81; 95% CI, 1.07-31.59) and symptom improvement at 3 month (OR, 28.90; 95% CI, 5.29-157.82) were associated with the improvement of dyspepsia at 1 year. Among the successfully eradicated FD patients (n = 67), male (P = 0.013) and higher initial BMI (P = 0.016) were associated with the improvement of dyspepsia at 1 year.CONCLUSIONS:
H. pylori eradication improved FD symptoms, as well as gastritis at 1 year, suggesting that inflammation mediates FD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Rome
/
Multivariate Analysis
/
Follow-Up Studies
/
Interleukin-8
/
Helicobacter pylori
/
Interleukin-6
/
Interleukin-10
/
Helicobacter
/
Proton Pumps
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Journal of Neurogastroenterology and Motility
Year:
2013
Type:
Article
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