Sedative-Hypnotic and Receptor Binding Studies of Fermented Marine Organisms
Biomolecules & Therapeutics
;
: 479-485, 2015.
Article
in English
| WPRIM
| ID: wpr-86469
ABSTRACT
This study was performed to investigate the sedative-hypnotic activity of gamma-aminobutyric acid (GABA)-enriched fermented marine organisms (FMO), including sea tangle (FST) and oyster (FO) by Lactobacillus brevis BJ20 (L. brevis BJ20). FST and FO were tested for their binding activity of the GABA(A)-benzodiazepine and 5-HT(2C) receptors, which are well-known molecular targets for sleep aids. We also measured the sleep latency and sleep duration during pentobarbital-induced sleep in mice after oral administration of FST and FO. In GABA(A) and 5-HT(2C) receptor binding assays, FST displayed an effective concentration-dependent binding affinity to GABA(A) receptor, similar to the binding affinity to 5-HT(2C) receptor. FO exhibited higher affinity to 5-HT(2C) receptor, compared with the GABA(A) receptor. The oral administration of FST and FO produced a dose-dependent decrease in sleep latency and increase in sleep duration in pentobarbital-induced hypnosis. The data demonstrate that FST and FO possess sedative-hypnotic activity possibly by modulating GABA(A) and 5-HT(2C) receptors. We propose that FST and FO might be effective agents for treatment of insomnia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ostreidae
/
Administration, Oral
/
Receptors, GABA-A
/
Receptor, Serotonin, 5-HT2C
/
Levilactobacillus brevis
/
Aquatic Organisms
/
Gamma-Aminobutyric Acid
/
Hypnosis
/
Sleep Initiation and Maintenance Disorders
Limits:
Animals
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS