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The effects of levetiracetam on bone metabolism and thyroid hormone levels in children with epilepsy for one year / 中国小儿急救医学
Chinese Pediatric Emergency Medicine ; (12): 362-365, 2020.
Article in Chinese | WPRIM | ID: wpr-864922
ABSTRACT

Objective:

To investigate the effects of levetiracetam on bone metabolism and thyroid hormone levels in children with epilepsy.

Methods:

A total of 20 children with epilepsy first diagnosed in our hospital from July 2016 to June 2017 were selected as the treatment group, the other 20 children who received physical examination in the same period were selected as the control group.The treatment group was given oral LEV monotherapy for 12 months.The changes of bone metabolism indexes[blood calcium, blood phosphorus, alkaline phosphatase activities, osteocalcin, parathyroid hormone, 25-(OH)D], bone mineral density(BMD)and serum thyroid hormone(triiodothyronine, tetraiodothyronine, free triiodothyronine, free thyroxine, thyroid stimulating hormone) in the control group and the treatment group were detected before, 6 and 12 months after medication.

Results:

(1)There were no statistically significant differences in bone metabolism indexes and BMD between the control group and the treatment group before medication( P>0.05). The differences showed no statistically significant in bone metabolism indexes and BMD among different time points of treatment group( P>0.05). (2)There were no significant differences in thyroid hormone levels between the control group and the treatment group before medication( P>0.05). There were no significant differences in thyroid hormone levels among different time points of treatment group ( P>0.05).

Conclusion:

Levetiracetam has no significant effects on bone metabolism and thyroid hormone level in epileptic children.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pediatric Emergency Medicine Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Pediatric Emergency Medicine Year: 2020 Type: Article