Gene Expression Analysis of Inflammatory Cytokines in Korean Psoriatic Patients
Annals of Dermatology
;
: 422-426, 2017.
Article
in English
| WPRIM
| ID: wpr-86519
ABSTRACT
BACKGROUND:
Although phenotypic heterogeneity of psoriasis is suggested by the alternate activation of either T-helper (Th)1-related or Th17-related cytokines, little is known about the mRNA levels of inflammatory cytokines.OBJECTIVE:
To investigate whether there is differential expression of Th1-related and Th17-related inflammatory cytokine genes 1) between psoriatic patients and healthy controls, and 2) between patients with different psoriasis phenotypes.METHODS:
Twenty-five patients with psoriasis (10 with guttate psoriasis and 15 with plaque psoriasis) and 5 healthy volunteers were enrolled in this study. The mRNA levels of circulating cytokines (interleukin [IL]-2, IL-12p40, interferon-γ, IL-17A, IL-22, and IL-23R) were measured by real-time reverse transcription polymerase chain reaction.RESULTS:
The comparison between psoriatic and healthy control samples revealed that IL-12p40, IL-17A, and IL-22 mRNA levels were significantly higher (approximately 4∼6 folds) in the patients with psoriasis. The mRNA levels of these six cytokines in the blood did not differ between the guttate and plaque psoriasis groups.CONCLUSION:
We found that the mRNA levels of blood inflammatory cytokines (IL-12p40, IL-17A, and IL-22) were significantly elevated in patients with psoriasis compared to the levels in healthy controls, but they did not significantly differ between patients with guttate and plaque type psoriasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Psoriasis
/
Population Characteristics
/
RNA, Messenger
/
Gene Expression
/
Polymerase Chain Reaction
/
Cytokines
/
Interleukin-17
/
Reverse Transcription
/
Interleukin-12 Subunit p40
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2017
Type:
Article
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