Neonatal umbilical cord blood vitamin D status and related factors / 中国新生儿科杂志

ABSTRACT

Objective To study neonatal umbilical cord blood vitamin D status and related factors.Method From January to March 2016,pregnant mothers and their neonates admitted to our hospital were enrolled.According to maternal intake of vitamin D in the third trimester,they were assigned into non supplement group,＜ 400 IU/d group and ≥ 400 IU/d group.Binary Logistic regression was used to examine factors related to neonatal umbilical cord blood vitamin D status.The predictive value of maternal third trimester vitamin D intaken and umbilical cord blood vitamin D level were determined using receiver operator characteristic (ROC) curve.Result A total of 109 newborns were enrolled in the study.The median concentration of 25 (OH)D in the umbilical cord blood was (17.5 ± 7.7) ng/ml.The incidences of 25 (OH) D sufficiency,insufficiency and deficiency was 33.9％ (37/109),22.0％ (24/109) and 39.4％(43/109),and 4 cases(4.6％) had serious deficiency.The median concentration of 25 (OH)D were (12.9 ± 6.5),(18.2 ± 6.9),(21.7 ± 8.4) ng/ml in the non-supplementation group,＜ 400 IU/d intake group and ≥400 IU/d intake group,respectively,with statistically significant differences(P ＜ 0.05).The three groups had similar birth weight,height,bregma and head circumference (P ＞ 0.05).25 (OH) D level in neonatal umbilical cord blood was positively correlated with the amount of maternal third trimester vitamin D supplementation (P ＜ 0.05).The Youden index was highest (0.403) when vitamin D supplement was 187 IU/d,the corresponding sensitivity was 0.514,the specificity was 0.889 and the area under the ROC curve was 0.777 (95％ CI 0.685 ～ 0.870).Conclusion Vitamin D insufficiency is common in neonatal umbilical cord blood among our patients.The maternal third trimester vitamin D supplementation dosage is related to the neonatal umbilical cord blood vitamin D level,which has a certain predictive value for vitamin D level in newborn.