Advances of ocular surface drug delivery system / 中华实验眼科杂志

ABSTRACT

Due to the anatomical and physical barriers, the low bioavailability of eye drops has become the primary problem in optimizing efficacy.Drug delivery system can reduce administration frequency and keep the therapeutic concentration while increasing ocular surface retention time and strengthening ability to permeate the cornea.Therefore, many ophthalmologists and relevant scientists focus on the ocular surface drug delivery system to overcome the drawback of low bioavailability.The advances of drug delivery system in ocular surface in the past decade were reviewed to give an introduction about the advantages and disadvantages as well as advances of nano-constructions, cyclodextrin and its derivatives, gels and contact lens.It is expected that ocular surface drug delivery systems could enhance the bioavailability to some extent, and have a good prospect in clinical practice when existing problems handled.