Teicoplanin is a potential inhibitor of SARS CoV-2 replication enzymes: A docking study
Asian Pacific Journal of Tropical Biomedicine
;
(12): 563-568, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-865428
ABSTRACT
Objective:
To explore potential inhibitors of viral enzymes of SARS CoV-2.Methods:
The in-silico docked potential of anti-viral, antibiotic, and analgesic drugs were studied for inhibition of the nonstructural protein (NSP) 9, NSP3, and NSP15 of SARS CoV-2 using recent structural peculiarities of these enzymes, 3D optimized structures of drugs and algorithm-based ligand inhibitory potential.Results:
Teicoplanin, azithromycin, and remdesivir potentially inhibited NSP9 (Dock-score 9?620, 5?472 and 6?252, respectively), NSP3 (Dock-score 9?846, 5?604 and 5?548, respectively) and NSP15 (Dock-score 10?960, 6?414 and 6?002, respectively).Conclusions:
Teicoplanin acts as a significant receptor antagonist and potentially inhibits the SARS CoV-2 enzymes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2020
Type:
Article
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