Clinical significance of serum ischemia modified albumin in women with polycystic ovarian syndrome / 中国医师进修杂志

ABSTRACT

Objective:To investigate serum ischemia modified albumin (IMA) levels in patients with polycystic ovary syndrome (PCOS) and to analyze its association with PCOS.Methods:Eighty patients(observation group) who received treatment in Tonglu Maternal and Child Health Hospital during 2017—2018, and 75 cases of healthy physical examination women (control group) were enrolled. The level of serum IMA was detected, and the IMA index was calculate. The levels of body mass index (BMI) and biochemical indexes such as fasting blood-glucose, fasting insulin, glycosylated hemoglobin, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterin, high-sensitivity C-reactive protein (hs-CRP) were compared. Homeostasis model assessment evaluated the insulin resistance index (HOMA-IR), and the levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), estradiol (E 2) and prolactin (PRL) were detected by chemiluminesent immunoassay assay. The relationship between serum IMA and the index above mentioned were analyzed by Pearson correlation. Results:The level of IMA in observation group and control group was (86.4 ± 10.5) and (73.6 ± 7.84) kU/L, and there was significant difference ( P<0.05). The level of IMA index in observation group and control group was 93.21 ± 8.40, 74.60 ± 6.52, and there was significant difference ( P<0.05). The levels of serum fasting insulin, HOMA-IR, hs-CRP, LH, LH/FSH, T in observation group were significantly higher than those in control group (14.90 ± 6.23) mU/L vs. (9.21 ± 1.5) mU/L, 3.64 ± 1.35 vs. 1.89 ± 0.91, (2.84 ± 0.73) mg/L vs. (0.81 ± 0.13) mg/L, (7.34 ± 2.65) mU/L vs. (4.50 ± 2.25) mU/L, 1.75 ± 0.62 vs. 0.90 ± 0.33, (2.64 ± 1.25) ng/L vs. (1.26 ± 0.36) ng/L, and there were significant differences ( P<0.05). In observation group, the level of IMA had positive correlation with the levels of T and HOMA-IR ( r=0.47, P<0.05; r=0.58, P<0.05), and had no correlation with BMI ( P>0.05). Conclusions:The level of IMA in PCOS patients is increased, and detecting the level of IMA has important clinical significance in treatment and evaluation.