Effect of high flow nasal catheter ventilation in mechanical ventilation withdrawal of premature infants and its influence on blood gas analysis / 中国医师进修杂志

ABSTRACT

Objective:To investigate the effect of high flow nasal catheter ventilation (HFNC) in mechanical ventilation withdrawal of premature infants and its influence on blood gas analysis.Methods:The clinical data of 60 premature infants with mechanical ventilation from January 2017 to December 2018 in Huzhou Maternal and Child Health Hospital were analyzed retrospectively. After withdrawal, 30 premature infants treated with nasal continuous positive airway pressure (NCPAP) were as NCPAP group, and 30 premature infants treated with HFNC were as HFNC group. The ventilation time, total oxygen use time, complications, and arterial partial pressure of oxygen (PaO 2) and arterial partial pressure of carbon dioxide (PaCO 2) 12 and 24 h after withdrawal were compared between 2 groups. Results:There were no statistical differences in ventilation time and total oxygen use time between 2 groups ( P>0.05). The incidence of complications in HFNC group was significantly lower than that in NCPAP group 13.33% (4/30) vs. 46.67% (14/30), and there was statistical difference ( P<0.05). The PaO 2 12 and 24 h after withdrawal in HFNC group was significantly higher than that in NCPAP group (68.83 ± 2.76) mmHg (1 mmHg=0.133 kPa) vs. (64.79 ± 2.31) mmHg and (78.46 ± 3.32) mmHg vs. (74.72 ± 2.18) mmHg, the PaCO 2 was significantly lower than that in NCPAP group (48.93 ± 2.51) mmHg vs. (52.31 ± 3.18) mmHg and (38.78 ± 4.23) mmHg vs. (43.67 ± 3.65) mmHg, and there were statistical differences ( P<0.05). Conclusions:HFNC is effective in mechanical ventilation withdrawal of premature infants, which can reduce complications and improve blood gas analysis.