The predictive value of the levels of carbohydrate antigen125 and N-terminal pro brain natriuretic peptide in peripheral blood on the readmission rate of patients with chronic heart failure / 中国医师进修杂志

ABSTRACT

Objective:To explore the predictive value of the levels of carbohydrate antigen125 (CA125) and N-terminal pro brain natriuretic peptide (NT-proBNP) in patients with chronic heart failure.Methods:One hundred and thirty-five patients with chronic heart failure admitted to Jiashan Hospital of Traditional Chinese Medicine from January 2018 to June 2019 were selected as the observation group. According to NYHA classification standard of cardiac function, 51 patients was Ⅱ grade, 36 patients was Ⅲ grade and 48 patients was Ⅳ grade. Eighty healthy people in same period were selected as the control group. The levels of CA125 and NT-proBNP were measured by enzyme-linked immunosorbent assay and immunofluorescence respectively. The levels of serum CA125 and NT-proBNP were compared between the two groups, and the mortality and readmission of the patients with different levels of CA125 and NT-proBNP were observed after 6 months of follow-up.Results:The serum CA125 and NT-proBNP levels in the observation group were higher than those in the control group [(87.81 ± 23.51) kU/L vs. (15.24 ± 3.24) kU/L, (397.25 ± 72.15) ng/L vs. (30.54 ± 3.41) ng/L] , and there were significant differences ( P<0.05). The levels of serum CA125 and NT-proBNP gradually increased with the NYHA classification. There was no significant difference in mortality between patients with different CA125 and NT-proBNP levels ( P>0.05). The readmission rate of CA125 ≥ 35 kU/L was higher than that of CA125<35 kU/L [64.00% (48/75) vs. 41.67%(25/60)] , the readmission rate of patients with NT-proBNP ≥ 450 ng/L was higher than that of patients with NT-proBNP<450 ng/L [65.57%(40/61) vs. 44.59%(33/74)], and there were significant differences ( P<0.05). Conclusions:The levels of CA125 and NT-proBNP in the peripheral blood of patients with chronic heart failure are significantly increased, which are closely related to the classification of cardiac function, and have an important predictive value for the readmission of patients.