Application of multi-parameters magnetic resonance imaging in diagnosis of prostate cancer patients and its relationship with expression level of tissue Ki-67 / 中国医师进修杂志

ABSTRACT

Objective:To explore application of multi-parameters magnetic resonance imaging(MRI) in diagnosis of prostate cancer patients, and to analyze the relationship between various parameters and expression level of tissue Ki-67.Methods:One hundred patients suspected with prostate cancer who had underwent multi-parameters MRI before surgery from June 2018 to June 2019 in Qinhuangdao Second Hospital were enrolled. Taking preoperative needle biopsy pathology as golden standard, it was confirmed that there were 50 cases with prostate cancer and 50 cases with benign prostatic hyperplasia (BPH). Imaging features were compared between the two groups. The patients with prostate cancer underwent transrectal ultrasound guided perineal prostate biopsy. The expression of Ki-67 in prostate tissue was detected. The relationship between parameters of multi-parameters MRI and expression level of Ki-67 was analyzed.Results:The combination diagnosis of T 2WI sequence, dynamic contrast-enhanced scan and diffusion-weighted imaging showed that there were 55 positive cases and 45 negative cases. The sensitivity and specificity of combined detection for diagnosis of prostate cancer were 92.00% (46/50) and 82.00% (41/50) respectively. Compared with BPH group, ADC and Tmax level in prostate cancer group were significantly decreased: (0.67 ± 0.13) × 10 -3 mm 2/s vs. (1.28 ± 0.17) × 10 -3 mm 2/s, [(17.43 ± 2.38) s vs. (22.37 ± 3.61) s, while SImax level was significantly increased: (1.85 ± 0.21)% vs. (1.48 ± 0.17)%, P<0.05. The positive index of Ki-67 in prostate cancer patients was significantly higher than that in BPH patients: (68.15 ± 6.31)% vs. (12.64 ± 2.58)%, P<0.05. The positive expression index of Ki-67 was negatively correlated with ADC ( r=-0.516, P<0.05), while positively correlated with maximum enhancement degree ( r=0.426, P<0.05). Conclusions:Multi-parameters MRI can help distinguish prostate cancer and BPH, which is of relatively higher sensitivity and specificity for diagnosis of prostate cancer. There is certain correlation between MRI findings and Ki67, which can reflect proliferation activity of tumor cells.