Effect of Xuebijing injection combined with low-molecular-weight heparin on sepsis patients and its influence on immune function and inflammatory factors / 中国医师进修杂志

ABSTRACT

Objective:To investigate the effect of Xuebijing injection combined with low-molecular-weight heparin on the immune function and inflammatory factors in patients with sepsis.Methods:The clinical data of 60 patients with sepsis admitted in the department of intensive care unit of Changzhou Wujin Hospital of Traditional Chinese Medicine from January 2018 to December 2019 were analyzed. The patients were randomly divided into observation group (30 cases) and control group (30 cases). The control group was treated with low-molecular-weight heparin sodium; the observation group was given Xuebijing injection combined with low-molecular-weight heparin. The course of treatment was 1 week in both groups. Heart rate (HR), body temperature, respiratory rate and white blood cell count (WBC), systemic infection related organ failure scale (SOFA) score, acute physiology and chronic health evaluation (APACHE) Ⅱ score, immune function and inflammatory factors tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and interleukin-6 (IL-6) were compared between the two groups before and after treatment for 1 week.Results:After treatment, the levels of HR, body temperature, respiratory rate and WBC in the observation group were lower than those in the control group [(83.22 ± 4.34) beats/min vs. (89.14 ± 3.67) beats/min, (37.02 ± 0.37)℃ vs.(37.81 ± 0.4) ℃, (86.83 ± 4.56) times/min vs. (97.32 ± 6.17) times/min, (10.85 ± 1.28) × 10 9/L vs. (12.29 ± 1.34) × 10 9/L], and the differences were statistically significant ( t = 5.705, 7.330, 7.489, 4.256, P < 0.05). After treatment, the scores of SOFA and APACHEⅡ in the observation group were lower than those in the control group [(8.93 ± 1.42) scores vs. (13.24 ± 1.98) scores, (12.13 ± 2.19) scores vs. (15.52 ± 1.98) scores], and the differences were statistically significant ( t = 9.689, 6.289, P < 0.05). After treatment, the levels of CD 3+, CD 3+ CD 4+ and CD 4+/CD 8+ in the observation group were higher than those in the control group [(62.31 ± 5.21)% vs. (54.68 ± 3.75)%, (35.38 ± 2.98)% vs. (29.39 ± 3.10)%, 1.15 ± 0.24 vs. 1.47 ± 0.18], and the differences were statistically significant ( t = 6.510, 7.630, 7.050, P < 0.05). After treatment, the levels of TNF-α, CRP and IL-6 in the observation group were lower than those in the control group [(23.94 ± 4.63) μg/L vs. (37.91 ± 3.6) μg/L, (43.17 ± 9.93) mg/L vs. (75.23 ± 15.42) mg/L, (34.21 ± 4.28) μg/L vs. (48.93 ± 5.12) μg/L], and the differences were statistically significant ( t = 12.978, 9.574, 12.082, P < 0.05). Conclusions:Xuebijing injection combined with low-molecular-weight heparin on sepsis patients can reduce the HR, body temperature, respiratory rate and WBC, reduce the patient's condition and organ damage, improve the immune function of the body, and reduce the inflammatory reaction in the body.