Analysis of serum vascular endothelial growth factor level of adults with Kaschin-Beck disease in Qinghai Plateau / 中华地方病学杂志

ABSTRACT

Objective:To understand the changes of serum vascular endothelial growth factor (VEGF) among adult Kaschin-Beck disease (KBD) in Qinghai Plateau, and to provide scientific data for prevention and control of KBD.Methods:From July to September in 2017, with a method of group design, according to "Diagnosis of Kaschin-Beck Disease", in the KBD endemic region of Xinghai and Guide counties in Hainan Tibetan Autonomous Prefecture of Qinghai Province, adult KBD patients and healthy people over 20 years old were selected as the KBD group and the internal control group, respectively. At the same time, healthy people over 20 years old were selected as the external control group in the non-KBD endemic region of Xunhua County with similar production scale and lifestyle. Fasting elbow vein blood samples in the 3 groups of people were collected. Serum VEGF levels were determined using a enzyme linked immunosorbent assay (ELISA) method.Results:Totally 272 persons were enrolled in the study, 104 cases in KBD group, 95 cases in internal control group and 73 cases in external control group. There were no significant differences in age and sex ratio between the three groups ( F = 2.236, P > 0.05; χ 2 = 3.135, P > 0.05). The serum concentrations of VEGF in KBD, internal control and external control groups were 504.23, 328.65 and 309.20 pg/ml, respectively, which were statistically significantly different ( Z = 150.472, P < 0.01). The serum concentration of VEGF in KBD group was higher than that of the internal and external control groups ( P < 0.05), but there was no significant difference between internal and external control groups ( P > 0.05). Conclusion:Serum VEGF level of KBD patients in Qinghai Plateau is higher than that of internal and external controls.