Research progress between hypoxia inducible factors and osteoarthritis / 中华地方病学杂志

ABSTRACT

Hypoxia-inducible factors (HIFs) play an important role in development, formation, regeneration and metabolism of extracellular matrix among bone and cartilage. Osteoarthritis (OA) is caused by many reasons, which result in degeneration and damage of joint cartilage and reaction regeneration of joint margin and subchondrobone. The etiology of OA remains uncertain; the relationship between HIFs and OA could provide scientific data for OA prevention and control.