Research progress on the relationship between microRNA and imbalance of bone turnover in skeletal fluorosis / 中华地方病学杂志

ABSTRACT

Skeletal fluorosis is an endemic disease prevalent in many countries in the world. China is one of the countries most affected by endemic fluorosis. The typical pathological change of skeletal fluorosis is accelerated bone turnover in bone tissue, during which a large number of transcription factors, signaling proteins and signaling pathways are expressed abnormally. However, the specific mechanism is not completely clear. MicroRNAs (miRNAs) are single-stranded non-coding RNA molecules involved in post-transcriptional regulation of genes. Studies have shown that miRNA can regulate the proliferation and differentiation of osteoblasts and osteoclasts, and is an important regulator of biological organ development and bone metabolic diseases. In this paper, the possible role of miRNA in the occurrence and development of skeletal fluorosis was discussed to provide ideas and directions for further study on the pathogenesis of skeletal fluorosis.