Research status of inhibitor of growth 4 and thyroid cancer / 中华地方病学杂志

ABSTRACT

As a member of the tumor suppressor gene inhibitor of growth (ING) family, ING4 participates in tumor growth, invasion and metastasis by affecting various cell processes such as cell cycle and apoptosis. As the most common malignant tumor of head and neck and endocrine, thyroid cancer has increased dramatically year by year, and the pathogenesis is still unclear. Its development involves the up-regulation of oncogene expression and down-regulation of tumor suppressor gene expression. In this paper, we describe the research status of ING4 and thyroid cancer by combining relevant reports and data at home and abroad.