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Alternate application efficacy of high-frequency oscillatory ventilation and constant-frequency mechanical ventilation in the treatment of premature infants with respiratory distress syndrome / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 541-545, 2020.
Article in Chinese | WPRIM | ID: wpr-866295
ABSTRACT

Objective:

To investigate the alternate application efficacy of high-frequency oscillatory ventilation and constant-frequency mechanical ventilation in the treatment of premature infants with respiratory distress syndrome.

Methods:

From April 2015 to August 2017, 174 premature infants with respiratory distress syndrome were chosen in this research and randomly divided into three groups.CF group was treated with constant-frequency mechanical ventilation, HF group was treated with high-frequency oscillatory ventilation, AP group was treated with alternate application of constant-frequency mechanical ventilation and high-frequency oscillatory ventilation.After treatment, the oxygen time, mechanical ventilation time, oxygenation, complications and survival in the three groups were compared.

Results:

The oxygen time, mechanical ventilation time of the AP group were shorter than those of the HF group and the CF group, the differences were statistically significant (all P<0.05). After treatment, the PaO 2 and PaO 2/FiO 2 were increased in each group, and the PaCO 2, OI and RI were decreased, and the differences were statistically significant compared with before treatment (all P<0.05). At 12 h, 24 h and 48 h after treatment, the PaO 2 and PaO 2/FiO 2 in the AP group were higher than those in the CF group and the HF group, the PaCO 2, OI and RI were lower than those in the CF group and the HF group(all P<0.05). There were no statistically significant differences in the incidence of complications and survival rate among the three groups(all P>0.05).

Conclusion:

Alternate application of high-frequency oscillatory ventilation and constant-frequency mechanical ventilation in the treatment of premature infants with respiratory distress syndrome can improve oxygenation, shorten oxygen time and mechanical ventilation time, with good safety.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article