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Effects of non-convulsive electroconvulsive therapy combined with sodium valproate sustained-release tablets on cognitive function and prognosis of bipolar disorder patients with manic episode / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1040-1045, 2020.
Article in Chinese | WPRIM | ID: wpr-866384
ABSTRACT

Objective:

To explore the effects of non-convulsive electroconvulsive therapy combined with sodium valproate sustained-release tablets on cognitive function and prognosis of bipolar disorder patients with manic episode.

Methods:

From January 2016 to January 2019, 100 patients with bipolar disorder manic episode admitted to the Seventh People's Hospital of Shaoxing were studied.According to the random number table method, 100 patients were divided into combined group (50 cases) and control group (50 cases). The patients in the control group were treated with valproate sustained-release tablets, and the patients in the combined group were treated with valproate sustained-release tablets combined with convulsive-free electroconvulsive therapy.The mental status, cognitive function and prognosis of the two groups were observed and compared.

Results:

There were no statistically significant differences in the scores of Brief Psychiatric Rating Scale(BPRS), Bech-Rafaelsen mania scale(BRMS) between the two groups before treatment (all P>0.05). The scores of BPRS and BRMS in the combined group after 4 weeks of treatment were (19.18±3.16)points, (6.16±2.71)points, respectively, which were significantly lower than those in the control group [(22.23±3.73)points, (8.23±3.03)points] ( t=4.411, 3.600, P=0.000, 0.000). After 4 weeks of treatment, the number of completed classification in the combined group was (3.23±0.58), which was significantly higher than that in the control group (3.23±0.58), and the number of errors, persistent responses and persistent errors in the combined group were (31.49±8.18), (21.66±7.48), (10.47±2.88), which were significantly lower than those in the control group[(43.26±10.32), (26.41±9.16), (15.12±3.43)], the differences were statistically significant ( t=5.029, 6.320, 2.840, 7.341, P=0.000, 0.000, 0.005, 0.000). The verbal intelligence quotient, operational intelligence quotient and IQ score of WAIS-RC scale in the combined group were (108.81±13.66)points, (107.41±15.23)points, (109.71±16.23)points, respectively, which were significantly higher than those in the control group [(101.55±10.08)points, (100.94±13.78)points, (102.48±14.64)points], the differences were statistically significant( t=3.023, 2.229, 2.339, P=0.003, 0.028, 0.021). The long-term memory, short-term memory, instantaneous memory and memory quotient in WMS scale scores of the combined group were (41.55±6.12)points, (58.16±7.16)points, (13.55±2.71)points, (104.46±11.69)points, respectively, which were significantly higher than those in the control group [(38.23±5.28)points, (49.11±5.31)points, (12.06±2.19)points, (98.71±9.51)points], the differences were statistically significant ( t=2.904, 7.178, 3.023, 2.698, P=0.004, 0.000, 0.003, 0.008). The onset time, restraint time and hospitalization time of the combined group were (16.44±5.06)d, (30.71±9.27)h, (49.54±9.28)d, respectively, which were significantly shorter than those of the control group [(16.44±5.06)d, (30.71±9.27)h, (33.48±7.12)d], the restraint times and recurrence times of the combined group were (3.21±0.84)times, (3.03±0.76)times, respectively, which were significantly less than those of the control group [(1.36±0.49)times, (1.22±0.41)times], and the hospitalization expense of the combined group was (6 155.79±678.11)CNY, which was significantly lower than that of the control group [(4 162.48±513.48)CNY], the differences were statistically significant ( t=7.341, 4.529, 9.708, 13.451, 14.821, 16.570, P=0.000).

Conclusion:

Non-convulsive electroconvulsive therapy combined with sodium valproate sustained-release tablets is superior to sodium valproate alone in the treatment of bipolar disorder manic episode.And it can significantly improve the mental status and cognitive function, promote the rapid recovery, shorten hospitalization time and reduce hospitalization cost.It is worthy of promotion in clinical practice.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article