Comparison of the effects of bubroscopolamine combined with diclofenac on pain relief and recurrence in patients with stone-forming renal colic / 中国基层医药

ABSTRACT

Objective:To compare the effects of bubroscopolamine combined with diclofenac on pain relief and recurrence in patients with stone-forming renal colic.Methods:From December 2016 to December 2018, 86 cases of calculus renal colic were selected.According to random number table method, the patients were randomly divided into control group and observation group, with 43 cases in each group.Both two groups were given plenty of antimicrobial agents and static drops of butyl bromide scopolamine treatment, the control group was intramuscularly injected diclofenac sodium, while the observation group was rectally administered diclofenac sodium suppositories.The pain relief of the two groups was observed, and the incidence of adverse reactions and clinical efficacy of the two groups were compared.Results:After 0.5 h of treatment, the total effective rate of pain relief in the control group was 88.37%(38/43), which was significantly higher than 48.84%(21/43) in the observation group (χ 2=8.384, P<0.05). The VAS score of the observation group was (2.62±1.02)points, which was significantly lower than that of the control group[(4.21±0.84)points]( t=4.394, P<0.05). After 1 h of treatment, there were no statistically significant differences in the total effective rate of pain relief and VAS score between the two groups (all P>0.05). The incidence and recurrence rates of adverse reactions in the control group were 18.60%(8/43) and 20.93%(9/43), respectively, which were significantly higher than those in the observation group [4.65%(2/43) and 4.65%(2/43), χ 2=7.394, 8.769, all P<0.05]. There was no statistically significant difference in pain relief between the two groups after secondary treatment (all P>0.05). Conclusion:The analgesic effect of intramuscular injection of diclofenac sodium is significantly faster than rectal administration in patients with stone renal colic, but the adverse reactions of this method are more and the curative effect lasted for a short time.Rectal administration of diclofenac sodium suppository is safe and stable for patients with stone renal colic, so it is worthy of popularizing in clinic.