Relationship between serum levels of sTWEAK, BNP, MMP-1 and left ventricular remodeling in patients with dilated cardiomyopathy / 中国基层医药

ABSTRACT

Objective:To explore the relationship between the levels of serum sTWEAK, BNP, MMP-1 and left ventricular remodeling in patients with dilated cardiomyopathy(DCM).Methods:From November 2018 to November 2019, 106 DCM patients admitted to Army No.72 Group Military′s Hospital were selected as DCM group, and 70 non-DCM peoplewho received physical examination at the same time were selected as control group.The serum levels of sTWEAK, BNP and MMP-1 were measured respectively, and LVEDD, LVEF and LVMI were measured by echocardiography.Pearson correlation analysis was carried out on the relationship between serological indicators and left ventricular remodeling.Results:There were statistically significant differences between the DCM group and the control group in ultrasonic index, serum sTWEAK, BNP and MMP-1 levels( F=1 447.751, 208.642, 147.46, 55.742, 319.916, 205.741, all P<0.05). Compared with the DCM group with heart function grade Ⅱ, the levels of LVEDd, LVMI, BNP, MMP-1 were higher and LVEF was lower in the DCM group with heart function grade Ⅲ( t=17.702, 19.308, 7.279, 24.511, 5.129, all P<0.05). The serum sTWEAK was negatively correlated with LVEDD and LVMI( r=-0.221, -0.462, all P<0.05), and positively correlated with LVEF( r=0.490, P<0.05). The BNP level was positively correlated with LVEDd and LVMI( r=0.667, 0.483, all P<0.05). The MMP-1 was positively correlated with LVEDd and LVMI( r=0.756, 0.562, all P<0.05). The BNP and MMP-1 were negatively correlated with LVEF( r=-0.476, -0.404, all P<0.05). Conclusion:The serum level of sTWEAK decreased in DCM patients, while BNP and MMP-1 increased in DCM patients.All three indicators can reflect the severity of left ventricular remodeling.