Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 451-456, 2014.
Article
in English
| WPRIM
| ID: wpr-86646
ABSTRACT
BACKGROUND:
Succinylcholine commonly produces frequent adverse effects, including muscle fasciculation and myalgia. The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.METHODS:
This randomized, double-blinded study was conducted in 100 patients randomly allocated into five groups of 20 patients each. Patients were randomized to receive 0.02, 0.03, 0.04, 0.05 and 0.06 mg/kg rocuronium as a precurarizing dose. Neuromuscular monitoring after each precurarizing dose was recorded from the adductor pollicis muscle using acceleromyography with train-of-four stimulation of the ulnar nerve. All patients received succinylcholine 1.5 mg/kg at 2 minutes after the precurarization, and were assessed the incidence and severity of fasciculations, while myalgia was assessed at 24 hours after surgery.RESULTS:
The incidence and severity of visible muscle fasciculation was significantly less with increasing the amount of precurarizing dose of rocuronium (P < 0.001). Those of myalgia tend to decrease according to increasing the amount of precurarizing dose of rocuronium, but there was no significance (P = 0.072). The onset time of succinylcholine was significantly longer with increasing the amount of precurarizing dose of rocuronium (P < 0.001).CONCLUSIONS:
Precurarization with 0.04 mg/kg rocuronium was the optimal dose considering the reduction in the incidence and severity of fasciculation and myalgia with acceptable onset time, and the safe and effective precurarization.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Succinylcholine
/
Ulnar Nerve
/
Incidence
/
Neuromuscular Blockade
/
Fasciculation
/
Neuromuscular Monitoring
/
Myalgia
Type of study:
Controlled clinical trial
/
Incidence study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Korean Journal of Anesthesiology
Year:
2014
Type:
Article
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