Analysis of 33 745 adverse drug reactions from 2015 to 2019 in Huainan City, Anhui province / 中国基层医药

ABSTRACT

Objective:To analyze the occurrence, characteristics, laws and influencing factors of adverse drug reactions (ADR), so as to provide basis for guiding clinical safe and rational drug use and improving monitoring work.Methods:Using EXCEL PivotTable, automatic σand other functions, 33 745 ADR reports in Huainan ADR monitoring system from 2015 to 2019 were statistically analyzed.Results:ADR 72.4% came from medical institutions (24 446/33 745), and 27.6% came from drug marketing license holders, operating companies and individuals (9 299/33 745). The age group with high incidence of ADR was >40-70 years old, accounting for 54.6% (18 430/33 745); the remaining age group accounted for 45.4% (15 315/33 745). Type of report serious accounted for 1.8% (619/33 745), general accounted for 98.2% (33 126/33 745), and new accounted for 24.8% (8 362/33 745). Involved 88 types of pharmaceutical dosage forms, injections had the most ADR, accounting for 52.5% (17 710/33 745), and the incidence of intravenous ADR accounted for 50.0% (16 873/33 745). Among the top 20 ADR reports, 13 anti-infective drugs accounted for 65.0%.Conclusion:The occurrence of ADR is related to the patients' age, dosage form, route of administration and variety of drugs.We should strengthen ADR monitoring of anti-infective drugs and intravenous routes of administration, strengthen monitoring and early warning of serious ADR, strictly follow the principle of rational drug use, use antibiotics rationally, reduce ADR occurrence and ensure drug safety.