Detection and analysis of respiratory pathogens in patients with acute exacerbation of chronic obstructive pulmonary disease / 中国基层医药

ABSTRACT

Objective:To detect and analyze the infections of respiratory pathogens in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:Through retrospective analysis, 335 AECOPD patients hospitalized from October 2016 to September 2018 in the First People′s Hospital of Pinghu were selected.The indirect immunofluorescence method was used to detect IgM antibody of eight kinds of respiratory pathogens, and the results were analyzed.Results:The positive rate of respiratory pathogens-IgM antibody in patients with AECOPD was 29.9%.There were 57 cases with one single pathogen infection, 36 cases with two pathogens mixed infection, 7 cases with three kinds of pathogens mixed infection.The influenza virus B [52.0%(78/150)] was the most common, followed by influenza virus A [27.3%(41/150)], the positive rates of pathogens were influenza virus B>influenza virus A>respiratory syncytial virus>parainfluenza virus>Legionella pneumophila>Mycoplasma pneumoniae>Chlamydia pneumoniae>adenovirus.There was no statistically significant difference in different age groups(χ 2=0.047, P=0.829). The positive rates of pathogens-IgM in spring[55.3%(63/114)] and winter[58.1%(54/93)] were higher than those in summer[26.2%(16/61)] and autumn[25.4%(17/67)], the differences were statistically significant(χ 2=30.398, P<0.01). Conclusion:AECOPD is closely related with respiratory pathogens, especially influenza virus.We should do preventive work well in epidemic season.