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Clinicopathological features and immunohistochemical analysis of 120 transrectal ultrasound guided prostate biopsies / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1751-1754, 2020.
Article in Chinese | WPRIM | ID: wpr-866488
ABSTRACT

Objective:

To investigate the clinical features and immunohistochemical analysis of 120 transrectal ultrasound-guided prostate biopsies, thus to improve the clinical and pathological diagnosis accuracy of prostate cancer.

Methods:

From July 2018 to July 2019, the clinical data of 120 patients with prostate disease underwent transrectal ultrasound guided prostate biopsy in the First People's Hospital of Yongkang were selected.The clinicopathological features and immunohistochemical analysis were performed in the biopsy samples.

Results:

Of the 120 patients, 45 patients with prostate cancer(PCA) were diagnosed by pathology, accounting for 37.5%; 3 patients with prostatic epithelial neoplasia(PIN) grade I, accounting for 2.5%; 55 patients with benign prostatic hyperplasia, accounting for 45.8%; 5 cases of atypical adenomatoid hyperplasia, accounting for 4.2%; 12 cases of chronic prostatitis, accounting for 10.0%.Pathological results showed that the glandular structure of the prostate cancer was disordered, complicated and diverse, interstitial infiltration, and partial invasion of the pathological changes of the nerve.According to the Gleason scoring method, among 45 patients with prostate cancer, 6 patients were highly differentiated adenocarcinoma(<5 points), 25 patients were moderately differentiated (6-7 points), and 14 patients were poorly differentiated (≥8 points). Immunohistochemical analysis showed that p63 and CK34βE12 expression was negative in prostate cancer patients, and P504S and PSA expression was positive.

Conclusion:

Transrectal ultrasound guided prostate puncture has great significance for the diagnosis of prostate cancer.It is safe, accurate and easy to operate.It is an effective diagnostic method.Comprehensive judgment of clinical pathological features and immunohistochemical analysis can help differential diagnosis of prostate diseases and improve the accuracy of diagnosis.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article