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Observation on the effect of mirtazapine combined with duloxetine in the treatment of depression complicated with insomnia / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy ; (12): 1866-1869, 2020.
Article in Chinese | WPRIM | ID: wpr-866514
ABSTRACT

Objective:

To observe the clinical effect of mirtazapine combined with duloxetine in the treatment of depression with insomnia.

Methods:

From June 2017 to August 2018, 82 patients with depression and insomnia were selected from the Seventh People's Hospital of Shaoxing.The patients were divided into the control group (41 cases) and the observation group (41 cases) by double color ball wagging method.The observation group was treated with mirtazapine in combination with duloxetine, and the control group was treated with duloxetine.Both two groups were treated for 6 weeks as a course of treatment.The scores of depression, sleep quality and the occurrence of adverse reactions were compared between the two groups.

Results:

At 2, 4 and 6 weeks after treatment, the depression scores of the observation group were (18.02±1.32)points, (11.02±1.12)points and (6.20±1.04)points, respectively, which were lower than those of the control group [(20.69 1.85)points, (12.96±1.55)points and (7.89±1.15)points], the differences between the two groups were statistically significant ( t=7.523, 6.496 and 6.979, all P<0.05). The scores of the Pitzburg sleep quality index scale in the observation group were (7.55±1.02)points, (6.22±1.01)points and (5.22±1.01)points, respectively, which were lower than those in the control group [(12.65±1.82)points, (9.89±1.67)points and (8.64±1.54)points], the differences between the two groups were statistically significant ( t=15.652, 12.041 and 11.891, all P<0.05). The incidence of adverse reactions in the observation group was 2.44% (1/40), which was lower than that in the control group [24.39% (10/40)], the difference was statistically significant(χ 2=8.505, P<0.05).

Conclusion:

The clinical effect of mirtazapine combined with duloxetine in the treatment of depression with insomnia is remarkable, which can significantly improve the sleep disorder and alleviate the depressive symptoms.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Primary Medicine and Pharmacy Year: 2020 Type: Article