Influence of modified catheter thrombolytic regimen on clinical efficacy and safety of patients with acute DVT / 中国基层医药

ABSTRACT

Objective:To investigate the influence of modified catheter thrombolytic regimen on clinical efficacy and safety of patients with acute deep vein thrombosis (DVT).Methods:From March 2016 to March 2018, 86 patients with acute DVT were chosen in the Central Hospital of Yuncheng and randomly divided into two groups by random drawing method, with 43 cases in each group.The control group received routine catheter thrombolytic regimen, and the observation group received modified catheter thrombolysis regimen.The postoperative detumescence rate, postoperative lower limb circumference difference, venous patency score before and after operation, postoperative venous patency rate, operation time, thrombolytic costs, urokinase dosage, reduction amount of hemoglobin after operation and incidence of complications after operation of the two groups were compared.Results:There were no statistically significant differences in the postoperative detumescence rate, postoperative lower limb circumference difference, venous patency score after operation, postoperative venous patency rate between the two groups[(81.52±3.05)% vs.(84.66±4.29)%; (1.10±0.34)cm vs.(1.24±0.39)cm; (2.40±0.53)points vs.(2.51±0.59)points; (63.16±6.98)% vs.(64.81±7.15)%; t=0.58, 0.70, 0.16, 0.25, all P>0.05]. The operation time and reduction amount of hemoglobin after operation of the observation group were significantly more than those of the control group[(42.81±6.17)min vs.(20.86±3.02)min; (12.84±3.96)g/L vs.(4.13±1.02)g/L; t=4.26, 3.51, P<0.05]. The thrombolytic costs and urokinase dosage of the observation group were significantly less than those of the control group[(4 129.25±584.57)CNY vs.(7 251.49±695.70)CNY; (79.17±10.79)×10 4U vs.(217.13±38.76)×10 4U; t=7.14, 10.26, all P<0.05]. There was no statistically significant difference in the incidence of complications after operation between the two groups (11.63% vs.9.30%, χ 2=0.82, P>0.05). Conclusion:Compared with routine catheter thrombolytic regimen, modified catheter thrombolytic regimen in the treatment of patients with acute DVT has the same clinical effects and safety, and can efficiently reduce the treatment costs and the urokinase dosage, but may also increase the operation time and bleeding volume.