Study on serum insulin-like growth factor-1 level and its relationship with growth in children with short stature / 中国基层医药

ABSTRACT

Objective:To analyze the etiology of 134 short stature children and to explore the relationship between serum insulin-like growth factor-1(IGF-1) level and growth.Methods:From July 2015 to July 2019, 134 children aged 4-15 years with short stature(short group) and 134 children aged 4-15 years without short stature and other organic diseases(control group) who were diagnosed and treated in the Second People's Hospital of Anhui Province were selected in the research.The early morning fasting serum IGF-1 determination and growth hormone(GH) stimulation test were conducted.The serum IGF-1 of short stature children of different types and ages were compared with the control group.Results:In the short group, 41 cases(30.6%) were idiopathic short stature(ISS), 80 cases(59.7%) were growth hormone deficiency(GHD), and 13 cases(9.7%) were other types of short stature.The serum IGF-1 levels of short stature children with complete GH deficiency, short stature children with partial GH deficiency and ISS children were (172.71±86.49)ng/mL, (167.61±100.10)ng/mL, (170.33±99.77)ng/mL, respectively, which were significantly lower than those of the control group [(365.33±96.42)ng/mL], the differences were statistically significant( t=-8.92, -13.96, -9.27, all P<0.01). The IGF-1 in short stature children was low correlated with height( r=0.357, P<0.01), but had no significant correlation with body mass and GH. Conclusion:GHD is the most common type of short stature children in Anhui province, followed by ISS.Determination of IGF-1 level can be used as a valuable indicator for screening and diagnosing short stature, but it is not meaningful for clinical differentiation of different types of short stature.For children with short stature, corresponding examination should be perfected to determine the cause, and treatment should be given due to the cause.