Clinical effect of Bifidobacterium combined with compound pepsin powder in the treatment of secondary diarrhea following bronchopneumonia in infants / 中国基层医药

ABSTRACT

Objective:To observe the clinical effect of Bifidobacterium combined with compound pepsin powder in the treatment of secondary diarrhea following bronchopneumonia in infants, so as to explore the best clinical treatment of the disease and promote the early recovery of children.Methods:From January 2018 to December 2018, 100 infants with secondary diarrhea following bronchopneumonia who admitted to Department of Pediatrics of the Fourth People's Hospital of Wenling were divided into group A( n=50) and group B( n=50) according to random number table method.Bifidobacterium treatment and Bifidobacterium combined with compound pepsin powder were given, respectively.The clinical efficacy, disappearance time of diarrhea and hospitalization time, levels of inflammatory factors[interleukin-6 (IL-6), tumor necrosis factorα (TNF- α)] and serological indicators[gastrin(GAS), plasma motilin(MOT), somatostatin(SS), diamine oxidase(DAO)] were compared between the two groups. Results:The total effective rate of group B(96.0%) was higher than that of group A(82.0%)(χ 2=4.184, P<0.05). The disappearance time of diarrhea and hospitalization time in group B[(2.5±1.0)d, (3.6±0.6)d] were shorter than those in group A[(4.1±1.3)d, (5.7±0.8)d]( t=3.762, 2.541, all P<0.05). The levels of IL-6 and TNF-in the group B[(10.5±2.1)ng/L, (12.6±3.5)ng/L] were lower than those in group A[(16.6±2.5)ng/L, (21.2±4.4)ng/L]( t=5.129, 6.118, all P<0.05). After treatment, the levels of GAS, MOT, SS, DAO in group B[(86.8±8.4)ng/L, (386.1±32.2)ng/L, (51.5±7.2)ng/L, (1.0±0.3)U/mL] were better than those in group A[(115.4±10.1)ng/L, (502.8±41.6)ng/L, (37.3±5.8)ng/L, (1.4±0.5)U/mL]( t=6.310, 21.576, 10.964, 5.683, all P<0.05). Conclusion:Bifidobacterium combined with compound pepsinase powder is effective in the treatment of infantile secondary diarrhea following bronchopneumonia.It can significantly shorten the disappearance time of diarrhea and hospitalization time, reduce the levels of inflammatory factors and improve serological indicators.It is worthy of implementation.