Clinical analysis of 30 cases with Stevens-Johnson syndrome / 中国基层医药

ABSTRACT

Objective:To analyze the clinical characteristics and treatment of Stevens-Johnson syndrome.Methods:The clinical data of 30 children with Stevens-Johnson syndrome admitted to our hospital in recent 3 years(January 2016-June 2019) were retrospectively analyzed.Results:Among the 30 cases, 18 cases were male and 12 cases were female, the ratio of male to female was 3 2.The average age of onset was (7.57±2.48)years, with the oldest age 13years and the youngest age was 2years.The 30 patients met the diagnostic criteria for Stevens-Johnson syndrome.Among the suspected allergen, there were 15 cases of antibiotics, accounting for 50%.There were 8 cases of antiepileptic drugs(4 cases of phenobarbital, 2 cases of carbamazepine and 2 cases of valproic acid), accounting for 26.7%.Five cases of NSAIDS (4 cases of ibuprofen and 2 cases of aspirin), accounted for 16.7%.Two cases had no specific sensitizing drugs, accounted for 6%.All 30 patients had oral mucosa and conjunctiva involvement, corneal ulcer complicated in 1 case.Vulva and genital were involved in 10 cases.All 30 cases received implosive therapy with methylprednisolone sodium succinate + intravenous gamma globulin, among which 3 cases were treated with plasma exchange due to obvious impairment of organ function.Four cases developed toxic epidermal necrolysis, three of which were treated with cyclosporine.One patient had neurological sequelae, manifested as consciousness disorder and limb movement disorder, and recovered after 2 months of rehabilitation treatment.Conclusion:For children with Stevens-Johnson syndrome, most of the children with abnormal liver function.The antiepileptic drugs and antibacterial drugs are the most susceptible drugs.After early identification, early use of high-dose glucocorticoid plus intravenous gamma globulin shock treatment, the prognosis of most patients is good.When the effect is not good, other immune inhibitors such as ciclosporin, biological agents and blood purification, etc.can also be used.