Clinical effect of Zhuling Zhixie decoction combined with montmorillonite powder in the treatment of children with enteritis / 中国基层医药

ABSTRACT

Objective:To observe the clinical efficacy and safety of Zhuling Zhixie decoction combined with montmorillonite powder in the treatment of children with enteritis.Methods:From March 2019 to March 2020, 148 children with enteritis in the Maternal and Child Health Hospital of Lishui were selected in the research and divided into control group( n=74) and study group( n=74) according to random number table method.The control group was treated with montmorillonite powder, the study group was treated with Zhuling Zhixie decoction combined with montmorillonite powder.The time of remission of enteritis related symptoms was counted, the curative effect of enteritis was evaluated, the changes of serum inflammatory factors before and after treatment were compared, and adverse drug reactions during treatment were observed. Results:The recovery time of fecal character, fever abatement time and antiemetic time in the study group[(3.26±0.63)d, (1.54±0.49)d and (2.48±0.51)d] were significantly shorter than those in the control group[(4.18±0.75)d, (2.07±0.54)d and (3.26±0.68)d] ( t=5.893, 3.162, 6.416, all P<0.05). The overall treatment efficiency of enteritis in the study group(95.95%) was significantly higher than that in the control group(81.08%)(χ 2=8.041, P<0.05). After treatment, the serum hs-CRP, TNF-α and IL-6 levels in the study group were significantly lower than those in the control group( t=7.536, 9.224, 8.675, all P<0.05). The overall incidence of adverse drug reactions in the study group(13.51%, 10/74) was not significantly different from that in the study group(12.16%, 9/74)(χ 2=0.060, P>0.05). Conclusion:Compared with the simple treatment of montmorillonite powder, Zhuling Zhixie decoction combined with montmorillonite powder can effectively shorten the course of children's enteritis, improve the curative effect, alleviate the gastrointestinal inflammatory reaction, with high safety, which is worthy of clinical application.