Analysis of the characteristics of capillary blood flow density and macular avascular area of retina in patients with acute central serous chorioretinopathy / 中国基层医药

ABSTRACT

Objective:To investigate the change characteristics of SCP/DCP blood flow density and FAZ in retina of patients with acute central serous chorioretinopathy (CSC).Methods:The clinical data of 45 patients(45 eyes) with acute CSC in our hospital from January 2017 to October 2019 were retrospectively analyzed.All patients included 45 lesion eyes and 45 healthy eyes were set as lesion eye group and healthy eye group respectively, and 30 healthy people with 30 eyes were set as control group.The FAZ, blood flow density, CMT and SFCT of different groups were compared, and the enhanced morphology of capillary blood flow was analyzed.Results:There was no statistically significant difference in FAZ level in SCP among the three groups( P>0.05). The FAZ in DCP of the lesion eye group[(0.81±0.19)mm 2] was significantly higher than that in the healthy eye group [(0.43±0.12)mm 2] and the control group [(0.38±0.08)mm 2]( t=3.17, 3.22, all P<0.05). The blood flow density in the SCP/DCP of the lesion eye group and healthy eye group were significantly lower than those in the control group( t=2.69, 3.01, all P<0.05). The levels of CMT and SFCT in the lesion eye group [(427.43±35.66)μm and (359.43±32.95)μm] were significantly higher than those in the healthy eye group [(276.35±17.02)μm and (260.38±25.66)μm] and the control group [(285.69±11.47)μm and (235.76±20.50)μm] ( t=8.17, 9.89; 10.26, 15.92; all P<0.05). There was no statistically significant difference in CMT level between the healthy eye group and the control group( P>0.05). The level of SFCT of the healthy eye group was significantly higher than that in the healthy eye group and control group( t=4.39, P<0.05). The results of optical coherence tomography showed that the local enhancement of capillary blood flow was seen in 23 eyes, and the diffuse enhancement of blood flow was seen in 22 eyes in the affected eye group, and there was subretinal effusion at the same time.In the healthy eye group, the signal changes of capillary strength and intensity were seen.In the control group, there was no significant change. Conclusion:The results of OCTA showed that in lesion eye group, local enhancement of capillary blood flow was seen in 23 eyes and diffuse enhancement of blood flow was seen in 22 eyes, and subretinal effusion was all found.In healthy eye group, even strong and weak signal changes of capillary were seen, while there were no above changes in control group.