Effect of interventional embolization in the treatment of liver cancer with portal vein tumor thrombus / 中国基层医药

ABSTRACT

Objective:To investigate the effect of radiological interventional embolization in the treatment of hepatocellular carcinoma with portal vein tumor thrombus, and its effect on the improvement of prognosis.Methods:A total of 100 cases of liver cancer with portal vein tumor thrombus from July 2017 to July 2019 in the People's Hospital of Putuo District of Zhoushan City were selected in the study.The patients were divided into observation group and control group according to the random digital table method, with 50 cases in each group.The control group was treated by hepatic artery chemotherapy alone, and the observation group was treated by transcatheter arterial chemoembolization.The therapeutic effect, liver function changes and quality of life scores were compared between the two groups.Results:In the observation group, 25 cases(50%) with liver tumor shrinking more than 50%, 10 cases(20%) with portal vein tumor thrombus disappearing, those were 16 cases(32%) and 5 cases(10%) in the control group, the differences were statistically significant between the groups(χ 2=6.310, 4.601, all P<0.05). After treatment, the serum albumin, alanine aminotransferase, albumin, platelet count and leukocyte count in the observation group were (23.80±10.60)μmol/L, (68.10±19.83)U/L, (338.60±50.16)g/L, (102.13±20.10)×10 9/L, (4.10±2.10)×10 9/L, respectively, which in the control group were (19.20±7.55)μmol/L, (64.10±11.25)U/L, (32.11±4.83)g/L, (110.45±28.64)×10 9/L, (4.83±2.83)×10 9/L, respectively, the differences between the two groups were statistically significant( t=7.158, 4.301, 82.441, 3.432, 3.645, all P<0.05). The total health score of quality of life in the observation group was (69.20±3.94)points, which was higher than that in the control group[(52.76±2.40)points]( t=25.303, P<0.05). Conclusions:Radiation interventional embolization for liver cancer with portal vein tumor thrombus can rapidly improve liver function and reduce liver cancer or portal vein tumor thrombus lesions.The effect is significant, which is of great significance for improving the quality of life of patients with liver cancer and portal vein tumor thrombosis.It is worthy of promotion.