Effect of magnesium sulfate combined with nifedipine on coagulation function, vascular endothelial function and pregnancy outcome in patients with pregnancy induced hypertension / 中国基层医药

ABSTRACT

Objective:To investigate the effect of magnesium sulfate combined with nifedipine on coagulation function, vascular endothelial function and pregnancy outcome in patients with pregnancy induced hypertension.Methods:From January 2019 to January 2020, 142 cases of pregnancy hypertension admitted to Wenling Maternal and Child Health Hospital were divided into observation group(71 cases) and control group(71 cases) according the random digital table method.The control group was treated with magnesium sulfate injection, and the observation group was treated with nifedipine sustained-release tablets on the basis of the control group.The course of treatment in both two groups was 10 days.The therapeutic effect, blood pressure, coagulation function, endothelial function and pregnancy outcome of the two groups were compared before and after treatment.Results:The total effective rate of the observation group(92.96%) was higher than that of the control group(77.47%)(χ 2=6.762, P<0.05). The systolic blood pressure [(126.52±7.97)mmHg] and diastolic blood pressure [(76.98±3.65)mmHg] in the observation group were lower than those in the control group [(137.83±10.23)mmHg and (85.21±5.12)mmHg] ( t=7.349, 11.029, all P<0.05). After treatment, the PT[(11.81±0.34)s] and APTT[(32.62±0.47)s] in the observation group were longer than those in the control group[(12.32±0.21)s and (31.45±0.58)s], while the FIB [(3.17±0.41)g/L] was lower than that in the control group [(3.83±0.36)g/L], and the difference was statistically significant between the two groups( t=10.753, 13.206, 10.193, all P<0.05). The level of serum NO [(69.32±4.26)mg/L] in the observation group was higher than that in the control group [(60.29±6.15)mg/L], while ET-1 [(62.15±6.78)mg/L] was lower than that in the control group [(74.39±10.29)mg/L] , and the difference was statistically significant between the two groups( t=10.170, 8.370, all P<0.05). The incidence of cesarean section(36.62%), fetal respiratory distress(5.63%), postpartum hemorrhage(4.23%) and premature rupture of membranes(8.45%) in the observation group were lower than those in the control group(53.52%, 25.35%, 26.76% and 22.54%)(χ 2=4.096, 10.542, 13.770, 5.379, all P<0.05). Conclusion:Magnesium sulfate combined with nifedipine can improve the coagulation function and vascular endothelial function of patients with pregnancy induced hypertension, and reduce adverse pregnancy outcome.