Clinical distribution characteristics and drug resistance trend in 462 strains of Staphylococcus aureus isolated from pediatric patients / 中国基层医药

ABSTRACT

Objective:To analyze the clinical distribution characteristics and drug resistance of Staphylococcus aureus infection and provide clinical basis for rational use of antibacterial drugs.Methods:From 2016 to 2019, 462 strains of Staphylococcus aureus were collected from sputum specimens of hospitalized children in Jingzhou Central Hospital.The clinical distribution characteristics of Staphylococcus aureus infection and drug resistance of various antibacterial drugs were analyzed.Results:Among 462 strains of Staphylococcus aureus infection, 285 strains were male, accounting for 61.7%, 177 strains were female, accounting for 38.3%.There was no statisticall significant difference between male and female children with Staphylococcus aureus pneumonia(χ 2=0.762, P=0.383). Staphylococcus aureus mainly infected children under 1 year old(χ 2=73.163, P<0.001), and the seasonal distribution was mainly in winter and spring(χ 2=27.656, P<0.001). A total of 462 strains of Staphylococcus aureus were detected, of which 363 strains(78.6%) were methicillin-sensitive Staphylococcus aureus(MSSA), and 99 strains(21.4%) were methicillin-resistant Staphylococcus aureus(MRSA). MSSA and MRSA were 100% sensitive to vancomycin, tigecycline, teicoplanin, rifampicin, linezolid, quinoprotein-daffodil and nitrofurantoin.The sensitivity of MSSA to levofloxacin, gentamicin, compound sulfamethoxazole, oxacillin, moxifloxacin, ciprofloxacin and tetracycline were 100.0%, 95.9%, 91.7%, 72.2%, 96.7%, 92.6% and 90.0%, respectively.The sensitivity of MRSA to levofloxacin, gentamicin, compound sulfamethoxazole, oxacillin, rifampicin, moxifloxacin, ciprofloxacin and tetracycline were 91.9%, 82.8%, 80.8%, 57.6%, 90.9%, 77.8% and 76.8%, respectively, and it suggested that the drug resistance rate of MRSA was higher than MSSA, and there was statistically significant difference.The antibiotics with high MSSA resistance rate were penicillin G(91.2%), erythromycin(61.7%), clindamycin(50.1%), MRSA was 100.0% resistant to penicillin G, erythromycin and clindamycin. Conclusion:The situation of clinical infection of Staphylococcus aureus in children is grim, and the Staphylococcus aureus detected in the specimens of respiratory tract infection in children is mainly MSSA, which has good sensitivity to most antibacterial drugs.MRSA and MSSA have obvious differences in drug resistance to various antibacterial drugs.Antibiotics should be used rationally, and nosocomial infection control should be strengthened to prevent and reduce the occurrence of MRSA.