Effect of multimodal therapy based on transurethral resection of bladder tumor on locally muscle invasive bladder cancer / 中国基层医药

ABSTRACT

Objective:To investigate the effect of multimodal therapy based on transurethral resection of bladder tumor (TUR-Bt) on locally muscle invasive bladder cancer (MIBC).Methods:From January 2011 to December 2015, 89 patients with locally MIBC in the General Hospital of Shanxi Yangquan Yangmei Group were enrolled in the study.Among them, 40 cases underwent multimodal therapy based on TUR-Bt and classified as observation group, including adjuvant chemotherapy with 2~3 courses at 2 weeks after TUR-Bt and radiotherapy according to pelvic imaging examination results.The other 49 cases underwent radical cystectomy (RC) were classified as control group.The clinical pathological data and recurrence rate were compared between the two groups.Results:Of 89 patients, 67 cases were male and 22 cases were female, aged (67.0±11.0)years.The preoperative T stage 50 cases in T2 stage and 39 cases in T3 stage; pathological grade 30 cases in G1, 30 cases in G2, and 29 cases in G3.There were no statistically significant differences in clinical pathological data between the two groups (χ 2=0.003, t=1.687, χ 2=0.051, 0.922, P=0.956, 0.096, 0.821, 0.662). In the observation group, there were 12 cases and 20 cases had recurrence within 1 and 3 years, respectively, and the incidence were 30.0% and 50.0%.Compared with 22.4% and 42.9% of the control group, there was no statistically significant difference (χ 2=0.655, 0.573, P=0.418, 0.449). In the observation group, the 3-year recurrence rate of patients with T2 before surgery was 34.8%, which was significantly lower than 70.6% of patients with T3, and the difference was statistically significant (χ 2=5.013, P=0.025). Conclusion:For locally MIBC, multimodal treatment based on TUR-Bt can achieve similar efficacy with RC, and they have similar risk of recurrence at 1 and 3 years after operation.