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Advances in the changes of macrophage metabolism and the regulation of immunometabolism during sepsis / 中华危重病急救医学
Chinese Critical Care Medicine ; (12): 249-252, 2020.
Article in Chinese | WPRIM | ID: wpr-866808
ABSTRACT
Immunopathogenesis of sepsis is a very complex process involving the innate immune responses mediated by mononuclear macrophages. However, the maintenance and change of macrophage function is closely associated with their immunometabolism. Macrophages take glucose oxidative phosphorylation as the main metabolic pathway under normal physiological conditions, M1 macrophages increase glucose uptake and anaerobic glycolysis, while M2 macrophages increase fatty acid uptake and oxidative phosphorylation efficiency. Recent findings showed that hypoxia-inducible factor-1α, succinate and glutamine were involved in macrophage function and metabolism regulation. Focusing on macrophages function and their immunometabolism changes in the immunopathogenesis of sepsis will make it possible to target immunometabolism as a breakthrough in the future therapy of sepsis.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Critical Care Medicine Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Critical Care Medicine Year: 2020 Type: Article