Effect of afternoon nap on cognitive function of patients with Alzheimer's disease and its related mechanisms / 中华行为医学与脑科学杂志

ABSTRACT

Alzheimer's disease (AD) is a degenerative disease of the central nervous system characterized by progressive cognitive and behavioral disorders.Clinical manifestations include memory impairment, aphasia, apraxia, impaired visual spatial function, executive power, decreased computing power, personality and behavior changes and so on.At present, the incidence of dementia is increasing year by year, causing a huge social burden, and there is still no effective treatment.Therefore, many scholars try to prevent and delay the occurrence of cognitive impairment through the identification and control of risk factors.Combining with previous studies, nap is helpful for the maintenance and consolidation of memory.This article discusses the effect of nap on cognitive function and its related mechanisms.First, nap can improve cognitive function, but it depends on the length, the frequency of the nap, and the difficulty of the task.Second, the effect of nap on cognition may be through inflammatory response, neuroendocrine, Aβ and gene polymorphism.In addition, this paper also proposes future research prospects in terms of standardized research methods, deepening research on relevant mechanisms, and lifestyle interventions in view of the lack of previous research.